RTG Mercator Seminar: Dr. Stefan Howorka - University College London

Sequencing of DNA is central in modern biosciences, drug discovery, and healthcare. DNA sequencing with nanopores is a next-generation technology offering rapid readout rates and was widely used during the Covid pandemic for strain identification. Nanopore sequencing involves directly reading single nucleic acid strands in label-free fashion using portable handheld devices. In my presentation, I will describe DNA sequencing with protein nanopores. I will also present recently developed protein-sensing nanopores composed of folded DNA origami. The presentation will conclude an the outlook on protein sequencing with nanopores.